Nucleic Acid Mass Spectrometry Array (SpectroCHIP Array) is an advanced biochip technology mainly used in genomics research and DNA sequencing. The chip is highly integrated and capable of performing simultaneous gene sequencing of multiple DNA samples on a single chip.
High-throughput optical detection technology is used for efficient and accurate DNA fragment analysis. Its design takes into account the need for a high degree of automation, enabling users to access large-scale genetic data in a more rapid and reliable manner.
The technology has a wide range of applications in disease research, personalized medicine and bioinformatics, and provides a powerful tool to accelerate the progress of genomics research and DNA sequencing. The innovative design of nucleic acid mass spectrometry microarrays has made them one of the technologies currently attracting much attention in the field of gene sequencing.
Core Technology of the Nucleic Acid Mass Spectrometry Chip
The core technology of the SpectroCHIP Arrays is mass spectrometry, which measures the mass-to-charge ratio of nucleic acid molecules using a mass spectrometer. The chip integrates hundreds to thousands of microarrays, each capable of analyzing different nucleic acid samples. Nucleic acid molecules in the samples are ionized and analyzed using a mass spectrometer. Based on the mass and charge of nucleic acid molecules, the mass spectrometer generates a mass spectrum, providing information about nucleic acid sequences and structures.
Nucleic acid mass spectrometry microarrays are highly integrated, allowing multiple nucleic acid samples to be analyzed simultaneously, speeding up the experimental process.
It is easy to use, usually requiring only a small number of samples, and can provide high quality data in a relatively short period of time.
This technology has a wide range of applications for genomics research, clinical diagnosis, drug development and personalized medicine.
Advantages of Mass Spectrometry Chips:
- High Throughput: Mass spectrometry chips enable the simultaneous processing of multiple nucleic acid samples, enhancing experimental efficiency, especially for large-scale genomics research.
- High Sensitivity: This technology can detect nucleic acid molecules at extremely low concentrations, making it useful for the detection of rare variations or trace amounts of nucleic acids.
- High Resolution: Mass spectrometry chips provide high-resolution information about nucleic acid sequences, suitable for genotype analysis, variation detection, and sequence determination.
- Rapid Results: Compared to traditional nucleic acid analysis methods, mass spectrometry chips typically provide results in a shorter time, aiding rapid decision-making and applications.
Applications of SpectroCHIP Arrays:
- Genomics Research: Mass spectrometry analysis chips can be used for large-scale genome sequencing, single-nucleotide polymorphism (SNP) analysis, and epigenetics research.
- Clinical Diagnostics: In cancer diagnosis, identification of infectious pathogens, drug sensitivity testing, and genetic disease screening, mass spectrometry analysis chips have significant application value.
- Drug Development: This technology is used for screening potential drug targets, studying drug interactions, and assessing drug metabolism and toxicity.
- Personalized Medicine: Mass spectrometry analysis chips can be employed to customize individualized treatment plans, such as selecting optimal drugs based on a patient's genotype.
In conclusion, the Nucleic Acid Mass Spectrometry Chip represents a significant advancement in the field of biotechnology, providing an efficient, accurate, and rapid solution for high-throughput analysis of nucleic acid molecules. With its widespread applications, it holds great promise in advancing genomics research and clinical medicine, contributing significantly to the development of these fields.
核酸质谱芯片制备
整个流程的核心在于通过光刻和气相沉积技术，在芯片表面构建出精确的氨基亲水点与疏水背景相结合的微图案。顶旭生物专注于核酸质谱芯片的研发与生产，具备从基板到成品的全流程自主制备能力，核心技术在于其精湛的表面化学修饰与微加工工艺。采用先进的气相沉积技术，首先在基片表面构建均匀、稳定的氨基硅烷亲水层，为核酸样品提供优异的锚定界面。随后，利用精密photolithography定义微点阵列图案，并通过二次气相沉积完成疏水化处理。最终，采用独特的剥离（Lift-off）技术，一步去除保护层，精准形成“氨基亲水点-氟化疏水背景”的微阵列结构。
顶旭生物产品
| Product Code | Outline （mm） | number of microarrays | Dot diameter （mm） | Thickness （mm） | Chip material | Price （CNY) |
| L0001 | 30.73*19.73 | 384 | 0.5 | 0.75 | Silicon | 500 |
| L0002 | 30.73*19.73 | 96 | 0.5 | 0.75 | Silicon | 500 |
顶旭生物
顶旭生物是一家专注于材料表面改性的高科技企业，我们致力于为生物医药领域提供领先的表面解决方案。对于核酸质谱检测这一精准、高效的技术平台，其性能高度依赖于芯片表面的化学特性。这正是顶旭生物的核心价值所在。
我们凭借深厚的表面修饰技术积累——包括精准的氨基化、疏水化及多种功能基团（醛基、环氧基等）定制——能够为玻璃、聚合物乃至金属等各种芯片基材提供全流程的制备与改性服务.
在核酸质谱芯片的制备上，我们通过先进的气相沉积与光刻工艺，在芯片表面构建出微观尺度的“亲水-疏水”精确图案。这种经过特殊氨基化的亲水微点能高效富集核酸分子，显著提升检测的灵敏度与信噪比；而高度疏水的背景则确保了样点的形态均一、无扩散，保障了数据的高重复性与可靠性.
无论您是需要标准化的高性能质谱芯片，还是希望为您独特的实验设计与产品开发定制表面改性方案，顶旭生物都能以专业的技术实力为您提供支撑。
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