Microfluidic chip
Microfluidic plastic chips are an innovative technology for fluid manipulation and analysis at the microscale, widely applied in biomedical, chemical analysis, and laboratory research fields. To achieve mass production of these microchips, injection molding technology is extensively employed, providing an efficient, precise, and cost-effective solution for their manufacturing.
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Droplet Microfluidics is a microfluidic technology that manipulates and controls liquid droplets at the micrometer scale for various biological and chemical experiments. Integrating knowledge from microfluidics, chemical analysis, and biology, this technology offers advantages such as high integration, automation, high throughput, and low cost, opening new possibilities in laboratory research and clinical diagnostics. In this article, we will provide a detailed overview of the basic principles, applications, advantages, and challenges of droplet microfluidic chips.
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The Spiral Cell Sorting Chip is an innovative forefront microfluidic technology. Its unique design incorporates a spiral-shaped microchannel, enabling efficient continuous separation of suspended particles or cells by adjusting fluid velocity and spiral structure. This technology, renowned for its outstanding sorting efficiency, compact device size, and flexibility, finds extensive applications in cell sorting, particle separation, and biomedical research. This article delves into the principles, design features, and application areas of the Spiral Sorting Chip, with a particular focus on its significance in capturing circulating tumor cells (CTCs) for cancer research.
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The Step-Emulsification Chip is a microfluidic chip technology widely used in droplet microfluidics. Utilizing advanced emulsification techniques, it creates a step-like structure through layered formation, allowing efficient control and precise manipulation of droplets. This article delves into the technical principles, fabrication methods, application areas, advantages, challenges, and future prospects of Step-Emulsification Chips.
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In the ever-evolving field of biomedical technology, the single-molecule RNA analysis chip (amplification-free) has emerged as an advanced tool for biological analysis, garnering widespread attention. In comparison to traditional RNA analysis methods, the unique feature of no amplification and the high sensitivity to individual RNA molecules offer novel possibilities for early disease diagnosis and treatment. This article delves into the technical principles, application areas, advantages, challenges, and future prospects of the single-molecule RNA analysis chip.
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Microfluidic mother machine chip is an advanced biochip technology that integrates microfluidics and cell biology, aiming to simulate and study various stages of mother cells in the cell cycle and related molecular and biological processes. This technology utilizes microstructures such as microchannels, microreactors, and microvalves for highly precise manipulation and observation of mother cells at the microscopic scale. The following is a detailed overview of the mother machine chip, covering its principles, applications, advantages, and potential impact on cell biology and medical research.
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Cell capture chips represent an advanced application of microfluidic technology widely employed in biomedical research, medical diagnostics, and life sciences. This technology achieves efficient capture, positioning, and analysis of cells through intricate fluidic channels and functional surface structures. This article provides a detailed overview of the principles, application areas, advantages, and future trends of cell capture chips.
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Plant microfluidic chips are increasingly important tools in the field of plant science, with applications spanning plant growth, plant physiology, and plant stress responses. These chips leverage microfluidic technology to finely control and analyze plants through microchannels and microreactors, providing a novel approach to studying plant growth and development, metabolic processes, and plant responses to environmental changes. The following is an overview of plant microfluidic chips, including their principles, applications, advantages, and potential contributions to plant science research.
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The Lipid Nanoparticle Chip (LNP Chip) is an advanced technology widely used in the field of nanotechnology. It is designed based on the unique structure of lipid nanoparticles to achieve efficient drug delivery and biomedical research. This article will delve into the principles, structural design, performance characteristics, and applications in drug delivery and biomedical research of the Lipid Nanoparticle Chip.
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微流体技术的不断进步推动了生物芯片领域的发展，其中DLD（Deterministic lateral displacement）分选芯片作为一项创新技术，为细胞分选领域带来了新的可能性。 本文将详细介绍DLD分选芯片的原理、优势、应用领域以…
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环氧基修饰玻片通过化学方法在玻璃表面引入高反应活性的环氧基团（-CH(O)CH-），该类载玻片能与生物分子（如蛋白质、核酸）的氨基、羟基或硫醇基团发生共价结合，实现定向固定化。其核心优势在于高共价偶联效率与极低背景信号的平衡——既能高效捕获…
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PCR检测的精度瓶颈与表面处理技术的突破 临床PCR检测中，20%的假阴性结果竟源于一个容易被忽视的”隐形杀手”——样本吸附损失。当珍贵的核酸样本接触离心管、移液器吸头内壁时，传统耗材表面的非特异性吸附会像海绵一样&…
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Microtiter plate is a laboratory tool widely used in high throughput screening (HTS), enzyme-linked immunosorbent assay (ELISA), cell culture, nucleic acid and protein assays (PCR, qPCR) and so on. Common specifications include 6-well, 24-well and 96-well, and the materials are mainly polystyrene and polypropylene. According to the experimental needs, choosing microtiter plates with different numbers of wells, volumes and surface treatments can significantly improve the experimental efficiency and data reliability.
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The Nucleic Acid Mass Spectrometry Chip (SpectroCHIP Array) is an advanced biochip technology primarily applied in genomics research and DNA sequencing. This chip features highly integrated functions, enabling simultaneous gene sequencing of multiple DNA samples on a single chip. Utilizing high-throughput optical detection technology allows efficient and precise analysis of DNA fragments
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The hydrophobic treatment of biochip surface is to make the surface hydrophobic by introducing hydrophobic modifier or changing the surface chemistry, so as to realize the effect of anti-sorption and anti-pollution to water or aqueous liquid. The following are some common hydrophobic treatment methods for biochip surfaces:
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Hydrophilic modification of the surface of biochips is to make the surface hydrophilic by introducing hydrophilic modifiers or changing the surface chemistry, so as to realize the adsorption and wetting effects on water or aqueous liquids. Hydrophilic modification can facilitate the interaction of biochips with aqueous liquids, which is beneficial for applications such as molecular recognition, cell culture and fluid manipulation. The following are some common methods of hydrophilic modification of biochip surfaces:
MoreMicrofluidic processing equipment
Dxfluidics Desktop Micro Lithography Machine is designed for the fabrication of micrometer-scale patterns, ensuring excellent pattern transfer accuracy. The equipment utilizes a UV LED cold light source, combined with double aspheric quartz lenses, to generate parallel light with a semi-angle of <2°. Compared to traditional contact exposure machines, its extremely compact size places it on the desktop, providing convenience and precision in operation.
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Dxfluidics Desktop Micro Lithography Machine is designed for the fabrication of micrometer-scale patterns, ensuring excellent pattern transfer accuracy. The equipment utilizes a UV LED cold light source, combined with double aspheric quartz lenses, to generate parallel light with a semi-angle of <2°. Compared to traditional contact exposure machines, its extremely compact size places it on the desktop, providing convenience and precision in operation.
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Fluorine oil, as a perfluoroalkane compound, is widely used as the continuous phase of water-in-oil droplets because of its low viscosity, high boiling point and good biocompatibility. What's more, according to the principle of similar solubility, fluorine oil is immiscible with hydrocarbon alkyl compounds, so fluorine oil, as a continuous phase, can be used to prepare not only water-in-oil droplets, but also acetonitrile-in-fluorine oil, DMF-in-fluorine oil, and methylene fluoride-in-fluorine oil...
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Silicon wafer plays an indispensable role in microfluidic chip fabrication and can be used to prepare SU8 molds, silicon molds, and silicon runner chips. SU-8 mold Silicon wafers are widely used in SU-8 mold preparation.SU-8 photoresist is a polymer material with excellent mechanical properties and chemical stability, which can be used to fabricate microchannels and microjunctions in microfluidic chip...
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Microfluidic chips utilize micromachining techniques to process tiny channels and microstructures onto micron-scale material surfaces to enable microfluidic control and manipulation. Common microfluidic chip polymer (plastic) materials include COC cyclic olefin polymers, PMMA and PC materials.
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SU-8 photoresist is a high-resolution, high-precision, high-adhesion negative photoresist, which is widely used in the field of micro and nanofabrication. In microfluidic chips, SU-8 photoresist is widely used in the preparation of microfluidic chips, which can be used to prepare microstructures such as microfluidic channels, reaction chambers, valves and pumps.
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Microfluidic chips are miniaturized laboratory systems for controlling and manipulating tiny liquid fluids. Among other things, the material of the chip is crucial as it can directly affect the performance and stability of the chip. One of the commonly used materials for microfluidic chips is glass. Glass has many advantages, such as excellent chemical stability, transparency, high temperature stability, and corrosion resistance. In addition, ...
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PDMS (polydimethylsiloxane) PDMS is a commonly used material for microfluidic chips, and its full name is polydimethylsiloxane.PDMS has the following advantages, which make it a commonly used material in microfluidic chip preparation: In conclusion, PDMS is one of the commonly used materials in microfluidic chip preparation, with good transparency, biocompatibility, flexibility and plasticity. ...
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