Microfluidic PEEK Chips/Cell Culture Chips
Many in vitro methods have long been used for high-throughput drug screening or toxicology testing. However, most of the currently available systems are only partial approximations of human biology and therefore have limited predictive power. Indeed, these systems are either based on human cell cultures, which are unable to capture the complexity of cell behavior in a three-dimensional (3D) environment, or on animal tissue fragments, which are 3D in nature but only partially biologically similar to human tissues, and are unable to account for interactions with other organs. To overcome these limitations, a new generation of bioreactors is being developed to generate multiple human cell-based tissue analogs in the same fluidic system to better reproduce the complexity and interconnections of human physiology. These efforts are aimed at creating multi-tissue organ systems (cardiovascular, gastrointestinal, musculoskeletal, etc.) and ultimately connecting them into an interconnected human-on-a-chip device that is capable of realistically recreating the complexity of the human body's response to disease and potential drug treatments.
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