{"id":5310,"date":"2025-11-12T10:52:02","date_gmt":"2025-11-12T02:52:02","guid":{"rendered":"https:\/\/www.dxfluidics.com\/?p=5310"},"modified":"2025-11-12T10:52:05","modified_gmt":"2025-11-12T02:52:05","slug":"%e5%90%88%e6%88%90%e7%bb%86%e8%83%9e%e4%b8%8e-3d-%e5%be%ae%e6%b5%81%e6%8e%a7%e8%8a%af%e7%89%87%e7%9a%84%e5%8a%9f%e8%83%bd%e6%95%b4%e5%90%88%ef%bc%9a%e5%99%a8%e5%ae%98%e8%8a%af%e7%89%87","status":"publish","type":"post","link":"https:\/\/www.dxfluidics.com\/en\/technical-support\/information\/5310\/%e5%90%88%e6%88%90%e7%bb%86%e8%83%9e%e4%b8%8e-3d-%e5%be%ae%e6%b5%81%e6%8e%a7%e8%8a%af%e7%89%87%e7%9a%84%e5%8a%9f%e8%83%bd%e6%95%b4%e5%90%88%ef%bc%9a%e5%99%a8%e5%ae%98%e8%8a%af%e7%89%87\/","title":{"rendered":"\u5408\u6210\u7ec6\u80de\u4e0e 3D \u5fae\u6d41\u63a7\u82af\u7247\u7684\u529f\u80fd\u6574\u5408\uff1a\u5668\u5b98\u82af\u7247\u6280\u672f\u7684\u7a81\u7834\u6027\u8fdb\u5c55"},"content":{"rendered":"<p 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src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/11\/\u56fe\u72472-1.png\" alt=\"\" class=\"wp-image-5311\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/11\/\u56fe\u72472-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/11\/\u56fe\u72472-1-9x12.png 9w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u56fe1. 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class=\"wp-image-5312\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/11\/\u56fe\u72473-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/11\/\u56fe\u72473-1-9x12.png 9w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u56fe2. \u80f6\u4f53\u4f53\u652f\u6491\u8102\u8d28\u53cc\u5c42\u7684\u5f62\u6210\u3002A\uff09\u5728\u6eb6\u6db2\u4e2d\uff08\u5de6\uff09\u548c\u5fae\u6d41\u63a7\u88c5\u7f6e\u5185\uff08\u53f3\uff09\uff0c\u4ece\u5c0f\u5355\u5c42\u56ca\u6ce1\uff08SUVs\uff09\u5728\u80f6\u4f53\u4f53\u4e0a\u5f62\u6210\u652f\u6491\u8102\u8d28\u53cc\u5c42\uff08SLB\uff09\u7684\u793a\u610f\u56fe\u3002B\uff09\u5728\u4e8c\u6c27\u5316\u7845\u80f6\u4f53\u4f53\u5468\u56f4\u5f62\u6210\u7684\u8102\u8d28\u5c42\uff08LissRhod B\u6807\u8bb0\u7684\u8102\u8d28\uff09\u7684\u4ee3\u8868\u6027\u660e\u573a\u548c\u5171\u805a\u7126\u663e\u5fae\u955c\u56fe\u50cf\u3002\u6bd4\u4f8b\u5c3a\u4e3a20 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class=\"wp-block-paragraph\"><strong>\u4e09\u3001\u5173\u952e\u5e94\u7528\uff1a\u6dcb\u5df4\u7ed3\u82af\u7247\u9a71\u52a8\u7684 T <\/strong><strong>\u7ec6\u80de\u9ad8\u6548\u6269\u589e<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u4e00\uff09\u6a21\u5757\u5316\u6dcb\u5df4\u7ed3\u82af\u7247\u7684\u8bbe\u8ba1\u4e0e\u6784\u5efa<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7814\u7a76\u57fa\u4e8e\u4e0a\u8ff0\u6280\u672f\u6784\u5efa\u4e86 \u201c\u5373\u63d2\u5373\u7528\u201d \u578b\u6dcb\u5df4\u7ed3\u82af\u7247\uff0c\u901a\u8fc7\u4e32\u8054\u4e24\u4e2a\u529f\u80fd\u6a21\u5757\u6a21\u62df\u6dcb\u5df4\u7ed3\u708e\u75c7\u7684\u4e0d\u540c\u9636\u6bb5\uff1a\u7b2c\u4e00\u6a21\u5757\uff08\u708e\u75c7\u521d\u671f\uff09\u91c7\u7528\u9ad8\u5bc6\u5ea6\u80f6\u4f53\u4f53\u7f51\u7edc\uff08\u81ea\u7531\u901a\u9053\u9762\u79ef 35%\uff09\uff0c\u8868\u9762\u8d1f\u8f7d\u9ad8\u6d53\u5ea6\u6297 CD3\/CD28 \u6297\u4f53\uff08300 \u5206\u5b50 \/\u03bcm\u00b2\uff09\uff0c\u5b9e\u73b0 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T\u7ec6\u80de\u4ee5\u53ca\u672a\u5904\u7406\u7684\u5bf9\u7167\u7ec4\u3002\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u5728\u82af\u7247\u4e0a\u57f9\u517b48\u5c0f\u65f6\u540e\uff0c\u518d\u5728\u57f9\u517b\u57fa\u4e2d\u57f9\u517b48\u5c0f\u65f6\u540e\u8fdb\u884c\u6d4b\u91cf\u3002\u7ed3\u679c\u4ee5\u5e73\u5747\u503c\u00b1\u6807\u51c6\u5dee\u8868\u793a\uff0c\\(n=4\\)\u6765\u81ea\u4e24\u4e2a\u4f9b\u4f53\u548c\u4e24\u4e2a\u6280\u672f\u91cd\u590d\u3002E\uff09\u57fa\u4e8eELISA\u7684IL-4\u3001IL-5\u3001TNF-\u03b1\u3001INF \\(- \\gamma\\)\u5206\u6ccc\u5b9a\u91cf\u5206\u6790\uff0c\u6837\u672c\u6765\u81ea\u5728\u82af\u7247I\u8bbe\u8ba1\u4e0a\u57f9\u517b\u7684\u539f\u4ee3\u4ebaCD8+ T\u7ec6\u80de\uff0c\u8be5\u82af\u7247\u8bbe\u8ba1\u7684\u7b2c\u4e8c\u4e2a\u6a21\u5757\u4e2d\u5177\u6709\u9ad8\u5bc6\u5ea6\u6216\u4f4e\u5bc6\u5ea6\u7684\u80f6\u4f53\u4f53\u7f51\u72b6\u7ed3\u6784\u3002\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u5728\u82af\u7247\u4e0a\u57f9\u517b48\u5c0f\u65f6\u540e\uff0c\u518d\u5728\u57f9\u517b\u57fa\u4e2d\u57f9\u517b48\u5c0f\u65f6\u540e\u8fdb\u884c\u6d4b\u91cf\u3002\u7ed3\u679c\u4ee5\u5e73\u5747\u503c\u00b1\u6807\u51c6\u5dee\u8868\u793a\uff0c4\u6765\u81ea\u4e24\u4e2a\u4f9b\u4f53\u548c\u4e24\u4e2a\u6280\u672f\u91cd\u590d\u3002F\u548cG \u4e0d\u540c\u82af\u7247\u8bbe\u8ba1\u6269\u589e\u540ePD-1+\u548cCTLA4+ T\u7ec6\u80de\u7fa4\u7684\u6d41\u5f0f\u7ec6\u80de\u672f\u5b9a\u91cf\u5206\u6790\u3002\u7ed3\u679c\u4ee5\u5e73\u5747\u503c\u00b1\u6807\u51c6\u5dee\u8868\u793a\uff0c\\(n=4\\)\u6765\u81ea\u4e24\u4e2a\u4f9b\u4f53\u548c\u4e24\u4e2a\u6280\u672f\u91cd\u590d\u3002\u53cc\u5411\u65b9\u5dee\u5206\u6790\uff0c* \\(^{*} p&lt;0.05\\)\uff0c\\(* * p&lt;0.005\\)\uff0cns=\u4e0d\u663e\u8457\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u56db\u3001\u884c\u4e1a\u4ef7\u503c\u4e0e\u672a\u6765\u5c55\u671b<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u4e00\uff09\u6280\u672f\u7a81\u7834\u7684\u884c\u4e1a\u610f\u4e49<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8be5\u7814\u7a76\u9996\u6b21\u5c06\u5408\u6210\u7ec6\u80de\u4ece \u201c\u5206\u6790\u5bf9\u8c61\u201d \u8f6c\u53d8\u4e3a\u5fae\u6d41\u63a7\u82af\u7247\u7684 \u201c\u529f\u80fd\u6838\u5fc3\u201d\uff0c\u5176\u521b\u65b0\u70b9\u5728\u4e8e\uff1a\u901a\u8fc7 PDMS \u82af\u7247\u52a0\u5de5\u4e0e\u5408\u6210\u751f\u7269\u5b66\u7684\u8de8\u754c\u878d\u5408\uff0c\u5b9e\u73b0\u4e86\u751f\u7269\u7269\u7406\u4fe1\u53f7\uff08\u914d\u4f53\u5bc6\u5ea6\u3001\u7a7a\u95f4\u9650\u5236\uff09\u4e0e\u751f\u5316\u4fe1\u53f7\uff08\u7ec6\u80de\u56e0\u5b50\u65f6\u5e8f\u91ca\u653e\uff09\u7684\u534f\u540c\u8c03\u63a7\u3002\u8fd9\u4e00\u7a81\u7834\u4e0d\u4ec5\u63a8\u52a8\u4e86\u5668\u5b98\u82af\u7247\u6280\u672f\u7684\u5347\u7ea7\uff0c\u4e5f\u4e3a\u5fae\u6d41\u63a7\u82af\u7247\u5b9a\u5236\u3001MEMS \u52a0\u5de5\u7b49\u4ea7\u4e1a\u94fe\u73af\u8282\u63d0\u4f9b\u4e86\u65b0\u7684\u5e94\u7528\u573a\u666f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u4ea7\u4e1a\u5316\u5c42\u9762\uff0c\u8be5\u6280\u672f\u53ef\u76f4\u63a5\u5e94\u7528\u4e8e\u514d\u75ab\u7ec6\u80de\u6cbb\u7597\u7684\u7ec6\u80de\u5236\u5907\u73af\u8282\uff0c\u901a\u8fc7\u5fae\u6d41\u63a7\u82af\u7247\u7684\u6807\u51c6\u5316\u751f\u4ea7\uff0c\u63d0\u5347 T \u7ec6\u80de\u6269\u589e\u7684 reproducibility \u4e0e\u89c4\u6a21\u5316\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u5176\u6a21\u5757\u5316\u8bbe\u8ba1\u517c\u5bb9\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\uff08\u5982 CAR-T \u7ec6\u80de\u3001\u5e72\u7ec6\u80de\uff09\u7684\u57f9\u517b\u9700\u6c42\uff0c\u4e3a\u591a\u5668\u5b98\u82af\u7247\u3001\u7c7b\u5668\u5b98\u82af\u7247\u7684\u96c6\u6210\u5960\u5b9a\u4e86\u57fa\u7840\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uff08\u4e8c\uff09\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672a\u6765\u7814\u7a76\u5c06\u805a\u7126\u4e09\u4e2a\u6838\u5fc3\u65b9\u5411\uff1a\u4e00\u662f\u4f18\u5316\u5408\u6210\u7ec6\u80de\u7684\u529f\u80fd\u591a\u6837\u6027\uff0c\u6574\u5408\u4f53\u5916\u8f6c\u5f55\u7ffb\u8bd1\u7cfb\u7edf\uff08TX\/TL\uff09\u4e0e\u5149\u9057\u4f20\u5b66\u5de5\u5177\uff0c\u5b9e\u73b0\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7684\u52a8\u6001\u8c03\u63a7\uff1b\u4e8c\u662f\u62d3\u5c55\u82af\u7247\u7684\u4e34\u5e8a\u9002\u7528\u6027\uff0c\u9488\u5bf9\u80bf\u7624\u7c7b\u5668\u5b98\u82af\u7247\u3001\u8840\u8111\u5c4f\u969c\u82af\u7247\u7b49\u7279\u5b9a\u573a\u666f\uff0c\u4f18\u5316 PDMS \u82af\u7247\u7684\u7ed3\u6784\u8bbe\u8ba1\u4e0e\u8868\u9762\u4fee\u9970\u7b56\u7565\uff1b\u4e09\u662f\u63a8\u52a8\u6280\u672f\u7684\u4ea7\u4e1a\u5316\u8f6c\u5316\uff0c\u5f00\u53d1\u4f4e\u6210\u672c\u7684\u5fae\u6d41\u63a7\u82af\u7247\u91cf\u4ea7\u5de5\u827a\uff0c\u7ed3\u5408\u5fae\u6d41\u63a7\u68c0\u6d4b\u4eea\u5b9e\u73b0\u6269\u589e\u8fc7\u7a0b\u7684\u5b9e\u65f6\u76d1\u6d4b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ece\u6280\u672f\u8fed\u4ee3\u6765\u770b\uff0c\u8be5\u7814\u7a76\u91c7\u7528\u7684\u80f6\u4f53\u4f53\u6574\u5408\u3001SLB \u4fee\u9970\u3001\u6c34\u51dd\u80f6\u63a7\u91ca\u7b49\u6280\u672f\uff0c\u53ef\u4e0e 3D \u6253\u5370\u5fae\u6d41\u63a7\u82af\u7247\u3001\u6570\u5b57\u5fae\u6d41\u63a7\u7b49\u65b0\u5174\u6280\u672f\u7ed3\u5408\uff0c\u8fdb\u4e00\u6b65\u63d0\u5347\u5668\u4ef6\u7684\u529f\u80fd\u590d\u6742\u5ea6\u4e0e\u64cd\u4f5c\u4fbf\u6377\u6027\u3002\u540c\u65f6\uff0c\u5176\u4e0e MEMS \u4ee3\u5de5\u3001\u5fae\u7eb3\u52a0\u5de5\u5b9e\u9a8c\u5ba4\u7684\u534f\u540c\uff0c\u5c06\u52a0\u901f\u5668\u5b98\u82af\u7247\u4ece\u5b9e\u9a8c\u5ba4\u8d70\u5411\u4e34\u5e8a\u5e94\u7528\u7684\u8fdb\u7a0b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>V. Conclusion<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5408\u6210\u7ec6\u80de\u4e0e 3D \u5fae\u6d41\u63a7\u82af\u7247\u7684\u529f\u80fd\u6574\u5408\uff0c\u4e3a\u5668\u5b98\u82af\u7247\u6280\u672f\u5f00\u8f9f\u4e86 \u201c\u4eba\u5de5\u7ec6\u80de\u9a71\u52a8\u201d \u7684\u65b0\u65b9\u5411\u3002\u8be5\u7814\u7a76\u901a\u8fc7 PDMS \u82af\u7247\u52a0\u5de5\u3001MEMS \u52a0\u5de5\u3001\u8868\u9762\u4fee\u9970\u7b49\u6838\u5fc3\u6280\u672f\u7684\u534f\u540c\u521b\u65b0\uff0c\u6784\u5efa\u4e86\u53ef\u6a21\u62df\u6dcb\u5df4\u7ed3\u52a8\u6001\u5fae\u73af\u5883\u7684\u529f\u80fd\u5668\u4ef6\uff0c\u5728 T 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