{"id":5224,"date":"2025-10-14T13:33:28","date_gmt":"2025-10-14T05:33:28","guid":{"rendered":"https:\/\/www.dxfluidics.com\/?p=5224"},"modified":"2025-10-14T13:33:31","modified_gmt":"2025-10-14T05:33:31","slug":"%e5%a4%b4%e9%a2%88%e9%83%a8%e7%99%8c%e5%99%a8%e5%ae%98%e8%8a%af%e7%89%87%e6%8a%80%e6%9c%af%e5%8f%8a-3d-%e6%a8%a1%e5%9e%8b%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/www.dxfluidics.com\/en\/technical-support\/information\/5224\/%e5%a4%b4%e9%a2%88%e9%83%a8%e7%99%8c%e5%99%a8%e5%ae%98%e8%8a%af%e7%89%87%e6%8a%80%e6%9c%af%e5%8f%8a-3d-%e6%a8%a1%e5%9e%8b%e7%a0%94%e7%a9%b6%e8%bf%9b%e5%b1%95\/","title":{"rendered":"\u5934\u9888\u90e8\u764c\u7814\u7a76\u4e2d\u5668\u5b98\u82af\u7247\u6280\u672f\u7684\u521b\u65b0\u5e94\u7528\u4e0e\u00a03D\u00a0\u6a21\u578b\u7a81\u7834"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">1.&nbsp;&nbsp;&nbsp; \u5f15\u8a00\uff1a\u5934\u9888\u90e8\u764c\u7684\u4e34\u5e8a\u6311\u6218\u4e0e\u4f20\u7edf\u6a21\u578b\u5c40\u9650<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5934\u9888\u90e8\u764c\uff08HNC\uff09\u4f5c\u4e3a\u5168\u7403\u7b2c\u516d\u5927\u5e38\u89c1\u6076\u6027\u80bf\u7624\uff0c\u6db5\u76d6\u53e3\u8154\u764c\u3001\u5589\u764c\u3001\u9f3b\u54bd\u764c\u7b49\u591a\u4e2a\u4e9a\u578b\uff0c\u5176\u4e2d\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\uff08HNSCC\uff09\u5360\u6bd4\u6700\u9ad8\uff0c\u4e14\u5b58\u5728 HPV \u9633\u6027\u4e0e HPV \u9634\u6027\u7684\u663e\u8457\u5f02\u8d28\u6027 \u2014\u2014HPV \u9633\u6027\u60a3\u8005\u867d\u6613\u53d1\u751f\u6dcb\u5df4\u7ed3\u8f6c\u79fb\uff0c\u4f46\u5bf9\u653e\u5316\u7597\u654f\u611f\u6027\u66f4\u9ad8\uff0c\u9884\u540e\u76f8\u5bf9\u8f83\u597d\uff0c\u800c HPV \u9634\u6027\u60a3\u8005\u591a\u4e0e\u70df\u9152\u66b4\u9732\u76f8\u5173\uff0c\u514d\u75ab\u6d78\u6da6\u4e0d\u8db3\u4e14\u6cbb\u7597\u54cd\u5e94\u6709\u9650\u3002\u5f53\u524d HNC \u6cbb\u7597\u4ee5\u624b\u672f\u3001\u653e\u5316\u7597\u53ca\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08\u5982 PD-1 \u6297\u4f53\uff09\u4e3a\u4e3b\uff0c\u4f46\u8fd1 50% \u60a3\u8005\u65e0\u6cd5\u83b7\u76ca\uff0c\u4e14\u6613\u51fa\u73b0\u5c40\u90e8\u590d\u53d1\u6216\u8fdc\u5904\u8f6c\u79fb\uff0c\u6838\u5fc3\u95ee\u9898\u5728\u4e8e\u4f20\u7edf\u7814\u7a76\u6a21\u578b\u96be\u4ee5\u7cbe\u51c6\u6a21\u62df\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u590d\u6742\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4f20\u7edf 2D \u7ec6\u80de\u57f9\u517b\u867d\u80fd\u5b9e\u73b0 HNSCC \u7ec6\u80de\u7cfb\uff08\u5982 UM-SCC-11B\u3001FaDu\uff09\u7684\u4f4e\u6210\u672c\u6269\u589e\uff0c\u5374\u65e0\u6cd5\u8fd8\u539f\u7ec6\u80de\u95f4\u901a\u8baf\u4e0e ECM\uff08\u7ec6\u80de\u5916\u57fa\u8d28\uff09\u76f8\u4e92\u4f5c\u7528\uff0c\u5bfc\u81f4\u57fa\u56e0\u8868\u8fbe\u8c31\u4e0e\u4f53\u5185\u80bf\u7624\u5dee\u5f02\u663e\u8457\uff1b\u60a3\u8005\u6765\u6e90\u5f02\u79cd\u79fb\u690d\uff08PDX\uff09\u6a21\u578b\u867d\u80fd\u90e8\u5206\u6a21\u62df\u80bf\u7624\u751f\u957f\uff0c\u5374\u5b58\u5728\u5c0f\u9f20\u57fa\u8d28\u66ff\u4ee3\u4eba\u7c7b\u57fa\u8d28\u3001\u514d\u75ab\u5fae\u73af\u5883\u7f3a\u5931\u53ca\u4f26\u7406\u4e89\u8bae\u7b49\u95ee\u9898\u3002\u8fd9\u4e9b\u5c40\u9650\u63a8\u52a8\u4e86 3D \u57f9\u517b\u6a21\u578b\u4e0e\u5668\u5b98\u82af\u7247\uff08OOC\uff09\u6280\u672f\u7684\u53d1\u5c55\uff0c\u800c<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-chip\/\">\u5fae\u6d41\u63a7\u82af\u7247<\/a><\/strong>\u3001<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-chip\/custom-chip\/146\/pdms%e8%8a%af%e7%89%87\/\">PDMS \u82af\u7247<\/a><\/strong>\u3001<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-chip\/organ-chip\/1373\/3d%e7%bb%86%e8%83%9e%e5%9f%b9%e5%85%bb%e8%8a%af%e7%89%87\/\">3D \u7ec6\u80de\u57f9\u517b\u82af\u7247<\/a><\/strong>\u7b49\u6280\u672f\u7684\u6210\u719f\uff0c\u8fdb\u4e00\u6b65\u4e3a HNC \u7814\u7a76\u63d0\u4f9b\u4e86\u66f4\u8d34\u8fd1\u751f\u7406\u7684\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"213\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72471-2.png\" alt=\"\" class=\"wp-image-5226\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72471-2.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72471-2-18x7.png 18w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5934\u9888\u90e8\u764c\u75c7\u53ca\u5176\u590d\u6742\u7684\u5fae\u73af\u5883 A. \u5934\u9888\u90e8\u80bf\u7624\u6700\u5e38\u89c1\u7684\u90e8\u4f4d\u5305\u62ec\uff1a\uff081\uff09\u53e3\u8154\u3001\uff082\uff09\u54bd\u3001\uff083\uff09\u5589\u3001\uff084\uff09\u9f3b\u8154\u548c\uff085\uff09\u7532\u72b6\u817a\uff1bB. \u5934\u9888\u90e8\u764c\u75c7\uff08HNC\uff09\u7684\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7531\u764c\u7ec6\u80de\u3001\u57fa\u8d28\u7ec6\u80de\uff08\u5982\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff09\u3001\u514d\u75ab\u7ec6\u80de\uff08\u5982B\u7ec6\u80de\u3001T\u7ec6\u80de\u3001\u81ea\u7136\u6740\u4f24\u7ec6\u80de\uff09\u548c\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u6210\u5206\uff08\u5982\u80f6\u539f\u86cb\u767d\u3001\u7ea4\u8fde\u86cb\u767d\uff09\u7ec4\u6210\uff0c\u8fd9\u4e9b\u6210\u5206\u5171\u540c\u4e0e\u5de8\u566c\u7ec6\u80de\u76f8\u5173\uff1b\u80bf\u7624\u76f8\u5173\u4e2d\u6027\u7c92\u7ec6\u80de\uff08TAN\uff09\u652f\u6301\u80bf\u7624\u8fdb\u5c55\u548c\u6cbb\u7597\u62b5\u6297\u3002\u7f29\u5199\uff1aCAF\uff0c\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff1bVEGF\uff0c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff1bTAM\uff0c\u80bf\u7624<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">2.&nbsp;&nbsp;&nbsp; HNC&nbsp;\u7814\u7a76\u4e2d&nbsp;3D&nbsp;\u6a21\u578b\u7684\u6280\u672f\u6f14\u8fdb\uff1a\u4ece\u7403\u72b6\u4f53\u5230\u7c7b\u5668\u5b98<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">3D \u6a21\u578b\u7684\u53d1\u5c55\u5df2\u4ece\u7b80\u5355\u7684\u80bf\u7624\u7403\u72b6\u4f53\u8fc8\u5411\u529f\u80fd\u5316\u7c7b\u5668\u5b98\uff0c\u9010\u6b65\u5b9e\u73b0\u5bf9 HNC \u5f02\u8d28\u6027\u4e0e TME \u7684\u6a21\u62df\uff1a<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>\u80bf\u7624\u7403\u72b6\u4f53\uff1a\u57fa\u7840 3D <\/strong><strong>\u6a21\u578b\u7684\u7a81\u7834<\/strong>\u80bf\u7624\u7403\u72b6\u4f53\u5206\u4e3a\u7ec6\u80de\u7cfb\u6765\u6e90\uff08MCTS\uff09\u4e0e\u7ec4\u7ec7\u6765\u6e90\u4e24\u7c7b\u3002MCTS \u901a\u8fc7 HNSCC \u7ec6\u80de\u7cfb\u5728 U \u578b\u5e95\u5fae\u5b54\u677f\u4e2d\u60ac\u6d6e\u57f9\u517b\u5f62\u6210\uff0c\u867d histological \u76f8\u4f3c\u5ea6\u6709\u9650\uff0c\u4f46\u80fd\u6a21\u62df\u80bf\u7624\u7684\u4ee3\u8c22\u68af\u5ea6\u4e0e\u591a\u7ec6\u80de\u8010\u836f\u6027\uff0c\u9002\u5408\u521d\u6b65\u836f\u7269\u7b5b\u9009\uff1b\u800c\u4ece HNC \u60a3\u8005\u7ec4\u7ec7\u89e3\u79bb\u83b7\u5f97\u7684\u7403\u72b6\u4f53\uff0c\u56e0\u4fdd\u7559\u4e86\u80bf\u7624\u5e72\u7ec6\u80de\uff08CSCs\uff09\u4e0e stromal \u7ec6\u80de\uff0c\u53ef\u66f4\u597d\u53cd\u6620\u539f\u53d1\u80bf\u7624\u7684\u5f02\u8d28\u6027\uff0c\u5c24\u5176\u5728\u8bc4\u4f30 CSCs \u76f8\u5173\u8010\u836f\u6027\u65f6\u4f18\u52bf\u663e\u8457\u3002\u8fd9\u7c7b\u6a21\u578b\u5e38\u9700\u642d\u914d<strong>\u5fae\u6d41\u63a7\u82af\u7247<\/strong>\u5b9e\u73b0\u52a8\u6001\u57f9\u517b\uff0c\u63d0\u5347\u7ec6\u80de\u6d3b\u6027\u4e0e\u5b9e\u9a8c\u91cd\u590d\u6027\u3002<\/li>\n\n\n\n<li><strong>\u80bf\u7624\u7c7b\u5668\u5b98\uff1a\u7cbe\u51c6\u6a21\u62df HNC \u75c5\u7406\u7279\u5f81<\/strong>\u80bf\u7624\u7c7b\u5668\u5b98\u901a\u8fc7 Matrigel \u7ed3\u5408\u751f\u957f\u56e0\u5b50\uff08\u5982 Wnt \u6fc0\u52a8\u5242\u3001TGF-\u03b2 \u6291\u5236\u5242\uff09\u6784\u5efa\uff0c\u53ef\u4ece\u60a3\u8005\u65b0\u9c9c\u80bf\u7624\u7ec4\u7ec7\u6216\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\uff08iPSCs\uff09\u5206\u5316\u800c\u6765\u3002\u5728\u9f3b\u54bd\u764c\u7814\u7a76\u4e2d\uff0c\u7c7b\u5668\u5b98\u6a21\u578b\u6210\u529f\u89e3\u51b3\u4e86 EB \u75c5\u6bd2\uff08EBV\uff09\u4f53\u5916\u611f\u67d3\u6548\u7387\u4f4e\u7684\u95ee\u9898 \u2014\u2014 \u901a\u8fc7\u6c14\u6db2\u754c\u9762\uff08ALI\uff09\u57f9\u517b\u7ed3\u5408<strong>PDMS \u82af\u7247<\/strong>\u7684\u900f\u6c14\u7279\u6027\uff0cEBV \u611f\u67d3\u7387\u663e\u8457\u63d0\u5347\uff0c\u4e3a HPV \u9634\u6027 HNC \u7684\u75c5\u6bd2\u81f4\u75c5\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u4e86\u5e73\u53f0\u3002\u6b64\u5916\uff0c<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-chip\/organ-chip\/1407\/%e7%b1%bb%e5%99%a8%e5%ae%98%e8%8a%af%e7%89%87\/\">\u7c7b\u5668\u5b98\u5fae\u6d41\u63a7\u82af\u7247<\/a><\/strong>\u80fd\u6574\u5408 CAFs\uff08\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff09\u4e0e\u514d\u75ab\u7ec6\u80de\uff0c\u6a21\u62df HNSCC \u4e2d CAFs \u5206\u6ccc IL-6\u3001VEGF \u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u7684\u8fc7\u7a0b\uff0c\u800c<strong>3D \u7ec6\u80de\u57f9\u517b\u82af\u7247<\/strong>\u7684\u5e94\u7528\u5219\u8fdb\u4e00\u6b65\u5b9e\u73b0\u4e86\u7c7b\u5668\u5b98\u7684\u957f\u671f\u52a8\u6001\u57f9\u517b\u4e0e\u5b9e\u65f6\u89c2\u5bdf\u3002<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"529\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72472-1.png\" alt=\"\" class=\"wp-image-5227\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72472-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72472-1-13x12.png 13w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u540c\u7684\u5668\u5b98\u82af\u7247\u8bbe\u8ba1\u9488\u5bf9\u5404\u79cd\u7814\u7a76\u76ee\u7684\u8fdb\u884c\u4e86\u5b9a\u5236\uff08A\uff09\u5355\u8154\u5ba4\u82af\u7247\u8bbe\u8ba1\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[71]\u3002\u7248\u6743\u6240\u67092023\uff0c\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u9662\u520a\uff1b\uff08B\uff09\u9ad8\u901a\u91cf\u591a\u9635\u5217\u82af\u7247\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[72]\u3002\u7248\u6743\u6240\u67092021\uff0c\u6bd2\u7406\u5b66\uff1b\uff08C\uff09\u5e73\u884c\u8154\u5ba4\u82af\u7247\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[73]\u3002\u7248\u6743\u6240\u67092021\uff0c\u81ea\u7136\u751f\u7269\u533b\u5b66\u5de5\u7a0b\uff1b\uff08D\uff09\u53cc\u5668\u5b98\u548c\u591a\u5668\u5b98\u4e92\u8054\u82af\u7247\u5e73\u53f0\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[74,75]\u3002\u7248\u6743\u6240\u67092018\uff0c\u79d1\u5b66\u62a5\u544a\uff1b\u7248\u6743\u6240\u67092020\uff0c\u81ea\u7136\u751f\u7269\u533b\u5b66\u5de5\u7a0b<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3.&nbsp;&nbsp;&nbsp; \u5668\u5b98\u82af\u7247\u6280\u672f\u5728&nbsp;HNC&nbsp;\u7814\u7a76\u4e2d\u7684\u6838\u5fc3\u5e94\u7528<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5668\u5b98\u82af\u7247\uff08OOC\uff09\u901a\u8fc7\u5fae\u6d41\u63a7\u6280\u672f\u6574\u5408\u7ec6\u80de\u3001ECM \u4e0e\u7269\u7406\u5fae\u73af\u5883\uff0c\u6210\u4e3a\u7a81\u7834 HNC \u7814\u7a76\u74f6\u9888\u7684\u5173\u952e\u5de5\u5177\uff0c\u5176\u6838\u5fc3\u5e94\u7528\u96c6\u4e2d\u5728\u4e09\u5927\u65b9\u5411\uff1a<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1)&nbsp;&nbsp;&nbsp; \u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u7cbe\u51c6\u590d\u523b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">HNC \u7684 TME \u7531\u80bf\u7624\u7ec6\u80de\u3001\u514d\u75ab\u7ec6\u80de\uff08T \u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\uff09\u3001CAFs \u53ca\u8840\u7ba1\u7f51\u7edc\u6784\u6210\uff0c\u5668\u5b98\u82af\u7247\u901a\u8fc7<strong>\u5fae\u6d41\u63a7\u52a0\u5de5<\/strong>\u4e0e<strong>MEMS <\/strong><strong>\u52a0\u5de5<\/strong>\u6280\u672f\u5b9e\u73b0\u591a\u7ec6\u80de\u5171\u57f9\u517b\u4e0e\u52a8\u6001\u704c\u6ce8\u3002\u4f8b\u5982\uff0c\u57fa\u4e8e<strong>PDMS <\/strong><strong>\u82af\u7247<\/strong>\u7684 HNC \u6a21\u578b\u91c7\u7528\u4e09\u5c42\u7ed3\u6784\uff1a\u9876\u5c42\u4e3a\u53e3\u8154\u4e0a\u76ae\u7ec6\u80de\uff08\u6a21\u62df\u9ecf\u819c\u5c42\uff09\uff0c\u4e2d\u5c42\u5d4c\u5165 CAFs \u4e0e\u80f6\u539f\u57fa\u8d28\uff0c\u5e95\u5c42\u4e3a\u5185\u76ae\u7ec6\u80de\u5f62\u6210\u7684\u8840\u7ba1\u901a\u9053\uff0c\u901a\u8fc7\u5fae\u6d41\u63a7\u6cf5\u5b9e\u73b0\u57f9\u517b\u57fa\u5faa\u73af\uff0c\u7cbe\u51c6\u6a21\u62df\u70df\u8349\u70df\u96fe\u6216\u57ce\u5e02\u9897\u7c92\u7269\uff08UPM\uff09\u5bf9\u547c\u5438\u9053\u9ecf\u819c\u7684\u635f\u4f24 \u2014\u2014 \u5b9e\u9a8c\u663e\u793a\uff0cUPM \u66b4\u9732\u4f1a\u964d\u4f4e PDMS \u82af\u7247\u4e2d\u4e0a\u76ae\u7ec6\u80de\u7684\u7d27\u5bc6\u8fde\u63a5\u86cb\u767d ZO-1 \u8868\u8fbe\uff0c\u7834\u574f\u9ecf\u819c\u5b8c\u6574\u6027\uff0c\u8fd9\u4e0e\u4e34\u5e8a\u4e2d\u70df\u9152\u76f8\u5173 HNC \u7684\u9ecf\u819c\u635f\u4f24\u673a\u5236\u9ad8\u5ea6\u4e00\u81f4\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6750\u6599\u9009\u62e9\u4e0a\uff0c<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-device\/pdms%e8%8a%af%e7%89%87%e5%8a%a0%e5%b7%a5%e8%ae%be%e5%a4%87\/\">PDMS \u52a0\u5de5\u8bbe\u5907<\/a><\/strong>\u5236\u4f5c\u7684\u82af\u7247\u56e0\u53ef\u8c03\u8282\u521a\u5ea6\uff08\u4f4e\u81f3 100kPa\uff09\u9002\u5408\u6a21\u62df\u8f6f\u7ec4\u7ec7\u5fae\u73af\u5883\uff0c\u800c\u642d\u914d<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-device\/su8%e6%a8%a1%e5%85%b7%e5%8a%a0%e5%b7%a5%e5%b9%b3%e5%8f%b0\/\">SU8 \u6a21\u5177<\/a><\/strong>\u6216<strong><a href=\"https:\/\/www.dxfluidics.com\/consumables\/906\/su-8%e5%85%89%e5%88%bb%e8%83%b6-%e6%98%be%e5%bd%b1%e6%b6%b2\/\">\u5149\u523b\u80f6\u6a21\u5177<\/a><\/strong>\u52a0\u5de5\u7684\u5fae\u901a\u9053\uff08\u76f4\u5f84 50-200\u03bcm\uff09\uff0c\u80fd\u5b9e\u73b0 ECM \u4e0e\u7ec6\u80de\u7684\u7cbe\u51c6\u5206\u5e03\uff1b\u5bf9\u4e8e\u9aa8\u4fb5\u72af\u578b HNC\uff08\u5982\u4e0b\u988c\u9aa8\u8f6c\u79fb\uff09\uff0c\u5219\u9700\u5728\u82af\u7247\u4e2d\u6574\u5408\u7f9f\u57fa\u78f7\u7070\u77f3\uff08HA\uff09\u6d82\u5c42\u652f\u67b6\uff0c\u7ed3\u5408<strong>\u5fae\u7eb3\u52a0\u5de5\u5e73\u53f0<\/strong>\u63d0\u5347\u9aa8\u57fa\u8d28\u6a21\u62df\u7cbe\u5ea6\u3002<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"202\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72473-1.png\" alt=\"\" class=\"wp-image-5228\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72473-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72473-1-18x7.png 18w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5668\u5b98\u82af\u7247\u5728\u80bf\u7624\u8f6c\u79fb\u548c\u836f\u7269\u6d4b\u8bd5\u4e2d\u7684\u5e94\u7528\u3002\uff08A\uff09\u80be\u764c\u7ec6\u80deCaki-1\u4e0e\u764c\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u5728\u4eff\u751f\u809d\u810f\u5fae\u73af\u5883\u82af\u7247\u6a21\u578b\u4e2d\u7684\u5171\u57f9\u517b\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[86]\u3002\u7248\u6743\u6240\u67092021\uff0c\u300a\u6cbb\u7597\u8bca\u65ad\u5b66\u300b\uff1b\uff08B\uff09\u591a\u5668\u5b98\u8f6c\u79fb\u82af\u7247\u6a21\u578b\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[87]\u3002\u7248\u6743\u6240\u67092016\uff0c\u300aACS\u5e94\u7528\u6750\u6599\u4e0e\u754c\u9762\u300b\uff1b\uff08C\uff09\u5e26\u6709CGG\u7684\u80ba\u764c\u7c7b\u5668\u5b98\u836f\u7269\u6d4b\u8bd5\u6a21\u578b\uff0c\u7528\u4e8e\u7b5b\u9009\u60a3\u8005\u6765\u6e90\u7684\u7c7b\u5668\u5b98\u5e76\u786e\u5b9a\u6700\u4f73\u836f\u7269\u6d53\u5ea6\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[89]\u3002\u7248\u6743\u6240\u67092013\uff0c\u300a\u751f\u7269\u6750\u6599\u300b\uff1b\uff08D\uff09\u4e00\u79cd\u9ad8\u901a\u91cf\u82af\u7247\u6a21\u578b\uff0c\u5229\u7528\u5fae\u67f1\u9635\u5217\u76d1\u6d4b\u80bf\u7624-\u514d\u75ab\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u6d4b\u8bd5\u6297PD-1\u5bf9\u4e73\u817a\u764c\u7403\u72b6\u4f53\u548cT\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[91]\u3002\u7248\u6743\u6240\u67092021\uff0c\u300aSmall\u300b<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"493\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72474-1.png\" alt=\"\" class=\"wp-image-5229\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72474-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72474-1-13x12.png 13w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u4ee3\u8868\u6027\u5934\u9888\u90e8\u764c\uff08HNC\uff093D\u6a21\u578b\u5e94\u7528\uff08A\uff09\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e0e\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u7ec6\u80de\u76843D TRACERs\u5171\u57f9\u517b\u6a21\u578b\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[90]\u3002\u7248\u6743\u6240\u67092021\uff0c\u300a\u751f\u7269\u6750\u6599\u300b\uff1b\uff08B\uff09\u6a21\u62df\u80bf\u7624\u8fdb\u5c55\u5e76\u6d4b\u8bd5\u57fa\u4e8e\u7eb3\u7c73\u9897\u7c92\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u76843D\u53e3\u8154\u764c\u6a21\u578b\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[93]\u3002\u7248\u6743\u6240\u67092023\uff0c\u300a\u5728\u4f53\u300b\uff1b\uff08C\uff09\u7528\u4e8e\u7814\u7a76\u75be\u75c5\u8fdb\u5c55\u548cEB\u75c5\u6bd2\u611f\u67d3\u7684\u9f3b\u54bd\u764c\u6c14\u6db2\u754c\u97623D\u57f9\u517b\u6a21\u578b\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[95]\u3002\u7248\u6743\u6240\u67092018\uff0c\u300amSphere\u300b<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">2)&nbsp;&nbsp;&nbsp; HNC&nbsp;\u8f6c\u79fb\u8fc7\u7a0b\u7684\u52a8\u6001\u5efa\u6a21<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u662f HPV \u9633\u6027 HNC \u7684\u5178\u578b\u7279\u5f81\uff0c\u4f20\u7edf\u6a21\u578b\u96be\u4ee5\u6355\u6349\u8f6c\u79fb\u7684\u52a8\u6001\u8fc7\u7a0b\uff0c\u800c<strong>\u8f6c\u79fb\u5668\u5b98\u82af\u7247<\/strong>\u901a\u8fc7\u591a\u8154\u5ba4\u8bbe\u8ba1\u6a21\u62df \u201c\u539f\u53d1\u7076 &#8211; \u5faa\u73af &#8211; \u7ee7\u53d1\u7076\u201d \u8def\u5f84\u3002\u4f8b\u5982\uff0c\u7532\u72b6\u817a &#8211; \u80ba\u8f6c\u79fb\u82af\u7247\u901a\u8fc7<strong>\u5fae\u6d41\u63a7\u5149\u523b<\/strong>\u6280\u672f\u6784\u5efa\u5e73\u884c\u5fae\u901a\u9053\uff0c\u4e00\u4fa7\u57f9\u517b\u7532\u72b6\u817a\u764c\u7ec6\u80de\uff08\u5982 Caki-1\uff09\uff0c\u53e6\u4e00\u4fa7\u4ee5\u80ba hydrogel \u6a21\u62df\u9776\u5668\u5b98\uff0c\u82af\u7247\u4e2d\u6d41\u52a8\u7684\u57f9\u517b\u57fa\u6a21\u62df\u8840\u6db2\u5faa\u73af \u2014\u2014 \u7814\u7a76\u53d1\u73b0\uff0c\u6572\u4f4e RCAN1.4 \u57fa\u56e0\u4f1a\u901a\u8fc7\u4e0a\u8c03 NFE2L3 \u4fc3\u8fdb\u764c\u7ec6\u80de\u4fb5\u88ad\uff0c\u4e14\u4e0d\u540c\u7ec6\u80de\u7cfb\u7684\u8f6c\u79fb\u80fd\u529b\u5dee\u5f02\u53ef\u901a\u8fc7\u82af\u7247\u5b9e\u65f6\u89c2\u5bdf\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8fd9\u7c7b\u6a21\u578b\u7684\u6784\u5efa\u4f9d\u8d56<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-device\/pdms%e8%8a%af%e7%89%87%e5%8a%a0%e5%b7%a5%e8%ae%be%e5%a4%87\/\">\u5668\u5b98\u82af\u7247\u52a0\u5de5\u8bbe\u5907<\/a><\/strong>\u4e0e<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-chip\/custom-chip\/\">\u5fae\u6d41\u63a7\u82af\u7247\u5b9a\u5236<\/a><\/strong>\u6280\u672f\uff0c\u4f8b\u5982\u91c7\u7528\u7d2b\u5916\u5149\u523b\u673a\u5236\u4f5c\u7684\u5fae\u67f1\u9635\u5217\uff0c\u53ef\u91cf\u5316\u764c\u7ec6\u80de\u7684\u8fc1\u79fb\u901f\u5ea6\uff0c\u800c<strong>3D \u7ec6\u80de\u57f9\u517b\u82af\u7247<\/strong>\u4e2d\u5d4c\u5165\u7684\u6dcb\u5df4\u5185\u76ae\u7ec6\u80de\uff0c\u80fd\u5206\u6ccc\u5de8\u566c\u7ec6\u80de\u8fc1\u79fb\u6291\u5236\u56e0\u5b50\uff08MIF\uff09\uff0c\u8fdb\u4e00\u6b65\u63ed\u793a HNC \u7ec6\u80de\u7684\u7cd6\u9175\u89e3\u4f9d\u8d56\u673a\u5236\uff0c\u4e3a\u6297\u8f6c\u79fb\u836f\u7269\u7814\u53d1\u63d0\u4f9b\u9776\u70b9\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">3)&nbsp;&nbsp;&nbsp; \u4e2a\u6027\u5316\u836f\u7269\u7b5b\u9009\u4e0e\u6cbb\u7597\u8bc4\u4f30<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">HNC \u7684\u5f02\u8d28\u6027\u8981\u6c42\u6cbb\u7597\u65b9\u6848\u4e2a\u4f53\u5316\uff0c\u5668\u5b98\u82af\u7247\u901a\u8fc7<strong>\u5fae\u6d41\u63a7\u82af\u7247\u5b9a\u5236<\/strong>\u5b9e\u73b0\u9ad8 &#8211; throughput \u836f\u7269\u6d4b\u8bd5\u3002\u4f8b\u5982\uff0c\u57fa\u4e8e<strong>\u5fae\u6d41\u63a7\u82af\u7247<\/strong>\u7684\u6d53\u5ea6\u68af\u5ea6\u53d1\u751f\u5668\uff08CGG\uff09\uff0c\u53ef\u5728\u5355\u82af\u7247\u4e0a\u751f\u6210 0.1-10\u03bcM \u7684\u836f\u7269\u6d53\u5ea6\u68af\u5ea6\uff0c\u642d\u914d\u60a3\u8005\u6765\u6e90 HNC \u7c7b\u5668\u5b98\uff0c\u5feb\u901f\u7b5b\u9009\u5316\u7597\u836f\u7269\uff08\u5982\u987a\u94c2\uff09\u6216\u514d\u75ab\u6291\u5236\u5242\uff08\u5982 PD-L1 \u6297\u4f53\uff09\u7684\u6700\u4f73\u5242\u91cf\u3002\u5728\u514d\u75ab\u6cbb\u7597\u6d4b\u8bd5\u4e2d\uff0c\u82af\u7247\u8fd8\u53ef\u6574\u5408\u5065\u5eb7\u4f9b\u4f53\u7684 PBMCs\uff08\u5916\u5468\u8840\u5355\u6838\u7ec6\u80de\uff09\uff0c\u89c2\u5bdf IDO1 \u6291\u5236\u5242\u5bf9 T \u7ec6\u80de\u8fc1\u79fb\u7684\u4fc3\u8fdb\u4f5c\u7528 \u2014\u2014 \u5b9e\u9a8c\u663e\u793a\uff0c\u8fd9\u7c7b<strong><a href=\"https:\/\/www.dxfluidics.com\/microfluidic-chip\/organ-chip\/1757\/%e6%af%8d%e7%bb%86%e8%83%9e%e8%8a%af%e7%89%87\/\">\u5fae\u6d41\u63a7\u7ec6\u80de\u57f9\u517b\u82af\u7247<\/a><\/strong>\u80fd\u51c6\u786e\u533a\u5206 HPV \u9633\u6027\u4e0e\u9634\u6027\u60a3\u8005\u5bf9 PD-1 \u6297\u4f53\u7684\u54cd\u5e94\u5dee\u5f02\uff0c\u54cd\u5e94\u7387\u4e0e\u4e34\u5e8a\u6570\u636e\uff0815-20%\uff09\u9ad8\u5ea6\u543b\u5408\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b64\u5916\uff0c<strong>\u5fae\u6d41\u63a7\u82af\u7247\u68c0\u6d4b\u4eea<\/strong>\u7684\u5e94\u7528\u5b9e\u73b0\u4e86\u836f\u7269\u4f5c\u7528\u7684\u5b9e\u65f6\u76d1\u6d4b\uff0c\u4f8b\u5982\u901a\u8fc7\u5fae\u7535\u6781\u9635\u5217\uff08MEA\uff09\u8bb0\u5f55 HNC \u7c7b\u5668\u5b98\u7684\u7535\u751f\u7406\u4fe1\u53f7\uff0c\u8bc4\u4f30\u836f\u7269\u5bf9\u80bf\u7624\u7ec6\u80de\u6d3b\u6027\u7684\u5f71\u54cd\uff1b\u800c<strong>PDMS <\/strong><strong>\u6a21\u5177<\/strong>\u5236\u4f5c\u7684\u53ef\u91cd\u590d\u82af\u7247\uff0c\u964d\u4f4e\u4e86\u4e2a\u6027\u5316\u6d4b\u8bd5\u7684\u6210\u672c\uff0c\u4e3a\u4e34\u5e8a\u8f6c\u5316\u63d0\u4f9b\u4e86\u53ef\u884c\u6027\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">4.&nbsp;&nbsp;&nbsp; HNC&nbsp;\u5668\u5b98\u82af\u7247\u7684\u5173\u952e\u6280\u672f\u652f\u6491\u4e0e\u4ea7\u4e1a\u534f\u540c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5668\u5b98\u82af\u7247\u7684\u6027\u80fd\u4f9d\u8d56\u6750\u6599\u3001\u52a0\u5de5\u4e0e\u8bbe\u5907\u7684\u534f\u540c\uff0c\u6838\u5fc3\u6280\u672f\u4e0e\u4ea7\u4e1a\u8d44\u6e90\u7684\u6574\u5408\u6210\u4e3a\u5173\u952e\uff1a<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>\u6750\u6599\u4f53\u7cfb\uff1a\u4ece PDMS <\/strong><strong>\u5230\u529f\u80fd\u5316\u57fa\u8d28PDMS <\/strong><strong>\u82af\u7247<\/strong>\u56e0\u5149\u5b66\u900f\u660e\u3001\u6c14\u4f53\u901a\u900f\u6027\u597d\uff0c\u6210\u4e3a HNC \u5668\u5b98\u82af\u7247\u7684\u4e3b\u6d41\u57fa\u6750\uff0c\u901a\u8fc7<strong>PDMS <\/strong><strong>\u52a0\u5de5\u8bbe\u5907<\/strong>\u53ef\u5b9e\u73b0\u521a\u5ea6\u8c03\u8282\uff08\u6dfb\u52a0\u56fa\u5316\u5242\u6bd4\u4f8b\uff09\uff1b\u5bf9\u4e8e\u9ecf\u819c\u7ec4\u7ec7\u6a21\u62df\uff0c\u9700\u7ed3\u5408\u8131\u7ec6\u80de ECM\uff08dECM\uff09\uff0c\u5982\u6c14\u7ba1\u9ecf\u819c\u6765\u6e90\u7684 dECM\uff0c\u4fdd\u7559\u5929\u7136\u751f\u5316\u4fe1\u53f7\uff0c\u652f\u6301\u4e0a\u76ae &#8211; \u5185\u76ae\u5171\u57f9\u517b\uff1b\u800c<strong>SU8 <\/strong><strong>\u6a21\u5177<\/strong>\u4e0e<strong>\u5149\u523b\u80f6\u6a21\u5177<\/strong>\u5219\u7528\u4e8e\u5fae\u901a\u9053\u7684\u9ad8\u7cbe\u5ea6\u52a0\u5de5\uff0c\u642d\u914d<strong>\u5149\u523b\u673a<\/strong>\uff08\u5982 UV-KUB3\uff09\u5b9e\u73b0 5-10\u03bcm \u7684\u5fae\u7ed3\u6784\u5206\u8fa8\u7387\uff0c\u6ee1\u8db3 MEMS \u52a0\u5de5\u9700\u6c42\u3002<\/li>\n\n\n\n<li><strong>\u52a0\u5de5\u4e0e\u8bbe\u5907\u6574\u5408\u5fae\u7eb3\u52a0\u5de5\u5e73\u53f0<\/strong>\u4e3a\u82af\u7247\u5236\u9020\u63d0\u4f9b\u6838\u5fc3\u652f\u6491\uff0c\u4f8b\u5982\u901a\u8fc7\u7535\u5b50\u675f\u5149\u523b\u6280\u672f\u5236\u4f5c\u7eb3\u7c73\u7ea7\u6d41\u9053\uff0c\u6a21\u62df HNC \u4e2d\u7684\u5fae\u8840\u7ba1\u7f51\u7edc\uff1b<strong>\u5fae\u6d41\u63a7\u5149\u523b<\/strong>\u6280\u672f\u5219\u5b9e\u73b0\u82af\u7247\u4e0e 3D \u57f9\u517b\u7684\u7ed3\u5408\uff0c\u5982\u5728\u82af\u7247\u8868\u9762\u5149\u523b\u51fa\u7ec6\u80de\u9ecf\u9644\u4f4d\u70b9\uff0c\u5f15\u5bfc\u80bf\u7624\u7ec6\u80de\u6709\u5e8f\u751f\u957f\u3002\u4ea7\u4e1a\u7aef\uff0c<strong>\u5fae\u6d41\u63a7\u82af\u7247\u4ee3\u5de5<\/strong>\u4f01\u4e1a\uff08\u5982\u82cf\u5dde\u5730\u533a\u76f8\u5173\u5382\u5546\uff09\u53ef\u63d0\u4f9b\u4ece\u8bbe\u8ba1\u5230\u91cf\u4ea7\u7684\u670d\u52a1\uff0c\u800c<strong>\u5668\u5b98\u82af\u7247\u52a0\u5de5\u8bbe\u5907<\/strong>\u7684\u6807\u51c6\u5316\uff08\u5982\u6a21\u5757\u5316\u6cf5\u4f53\u3001\u6e29\u63a7\u7cfb\u7edf\uff09\uff0c\u5219\u964d\u4f4e\u4e86\u5b9e\u9a8c\u5ba4\u7ea7\u82af\u7247\u7684\u5e94\u7528\u95e8\u69db\u3002<\/li>\n\n\n\n<li><strong>\u8de8\u9886\u57df\u6280\u672f\u878d\u5408<\/strong>AI \u4e0e\u673a\u5668\u4eba\u6280\u672f\u7684\u878d\u5165\u63d0\u5347\u4e86\u82af\u7247\u7684\u81ea\u52a8\u5316\u6c34\u5e73\uff0c\u4f8b\u5982\u901a\u8fc7\u673a\u5668\u89c6\u89c9\u8bc6\u522b<strong>\u5fae\u6d41\u63a7\u82af\u7247<\/strong>\u4e2d\u7684\u80bf\u7624\u7403\u72b6\u4f53\u5927\u5c0f\uff0c\u9884\u6d4b\u836f\u7269\u54cd\u5e94\uff1b\u673a\u5668\u4eba\u6db2\u4f53\u5904\u7406\u7cfb\u7edf\u5b9e\u73b0\u591a\u82af\u7247\u540c\u6b65\u704c\u6ce8\uff0c\u63d0\u5347\u5b9e\u9a8c throughput\u3002\u6b64\u5916\uff0c<strong>\u6570\u5b57\u5fae\u6d41\u63a7\u82af\u7247<\/strong>\u7684\u53d1\u5c55\uff0c\u8fdb\u4e00\u6b65\u7b80\u5316\u4e86\u6837\u54c1\u64cd\u4f5c\uff0c\u9002\u5408\u4e34\u5e8a\u573a\u666f\u4e0b\u7684\u5feb\u901f\u68c0\u6d4b\u3002<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"689\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72475-1.png\" alt=\"\" class=\"wp-image-5230\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72475-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72475-1-10x12.png 10w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u4e0e\u5934\u9888\u90e8\u764c\u75c7\u76f8\u5173\u7684\u4ee3\u8868\u6027\u5668\u5b98\u82af\u7247\u7814\u7a76\uff08A\uff09\u6e90\u81ea\u9f3b\u8154\u7684\u547c\u5438\u9053\u82af\u7247\uff0c\u7531\u4e09\u5c42\u7ec4\u6210\uff1a\u4e0a\u76ae\u5c42\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u5c42\u548c\u5185\u76ae\u5c42\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[104]\uff1b\uff08B\uff09\u7528\u4e8e\u820c\u764c\u7684\u5fae\u6d41\u63a7\u82af\u7247\u8bbe\u8ba1\u3002\u514d\u75ab\u7ec6\u80de\u52a0\u8f7d\u5728\u901a\u9053A\u4e2d\uff0c\u820c\u764c\u7ec6\u80de\u5728\u901a\u9053B\u4e2d\uff0c\u901a\u9053C\u7528\u4e8e\u6c34\u5408\u4f5c\u7528\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[110]\uff1b\uff08C\uff09\u6a21\u62df\u80bf\u7624\u5fae\u73af\u5883\u7684\u53e3\u8154\u764c\u5668\u5b98\u82af\u7247\uff0c\u793a\u610f\u56fe\u53ca\u4f53\u5916\u8868\u5f81\u3002\u7ecf\u8bb8\u53ef\u8f6c\u8f7d[112]<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"530\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72476-1.png\" alt=\"\" class=\"wp-image-5231\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72476-1.png 554w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2025\/10\/\u56fe\u72476-1-13x12.png 13w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u5934\u9888\u90e8\u764c\u82af\u7247\u80bf\u7624\u7684\u6784\u5efa\u7b56\u7565<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">5.&nbsp;&nbsp;&nbsp; \u5f53\u524d\u6311\u6218\u4e0e\u672a\u6765\u53d1\u5c55\u65b9\u5411<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u5c3d\u7ba1\u5668\u5b98\u82af\u7247\u5728 HNC \u7814\u7a76\u4e2d\u53d6\u5f97\u7a81\u7834\uff0c\u4ecd\u9762\u4e34\u4e09\u5927\u6311\u6218\uff1a<\/p>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li><strong>\u6807\u51c6\u5316\u4e0e\u91cd\u590d\u6027<\/strong>\uff1a\u4e0d\u540c\u5b9e\u9a8c\u5ba4\u7684\u82af\u7247\u8bbe\u8ba1\uff08\u5982\u6d41\u9053\u5c3a\u5bf8\u3001\u6750\u6599\u914d\u6bd4\uff09\u5dee\u5f02\u5bfc\u81f4\u6570\u636e\u96be\u4ee5\u6bd4\u5bf9\uff0c\u9700\u5efa\u7acb\u7edf\u4e00\u7684<strong>\u5fae\u6d41\u63a7\u82af\u7247<\/strong>\u6027\u80fd\u6807\u51c6\uff08\u5982\u6d41\u4f53\u526a\u5207\u529b\u3001\u7ec6\u80de\u5b58\u6d3b\u7387\uff09\uff0c\u56fd\u9645\u7ec4\u7ec7\uff08\u5982\u6b27\u6d32 Organ-on-Chip \u534f\u4f1a\uff09\u5df2\u542f\u52a8\u76f8\u5173\u5de5\u4f5c\uff1b<\/li>\n\n\n\n<li><strong>\u4e34\u5e8a\u8f6c\u5316\u6548\u7387<\/strong>\uff1a\u60a3\u8005\u6765\u6e90\u7ec4\u7ec7\u7684\u5904\u7406\u6d41\u7a0b\u590d\u6742\uff0c\u82af\u7247\u6d4b\u8bd5\u5468\u671f\uff08\u901a\u5e38 7-14 \u5929\uff09\u96be\u4ee5\u5339\u914d\u4e34\u5e8a\u6cbb\u7597\u51b3\u7b56\u9700\u6c42\uff0c\u9700\u4f18\u5316<strong>\u5fae\u6d41\u63a7\u82af\u7247\u5b9a\u5236<\/strong>\u6d41\u7a0b\uff0c\u5b9e\u73b0\u6d3b\u68c0\u6837\u672c\u7684\u5feb\u901f\u82af\u7247\u6784\u5efa\uff1b<\/li>\n\n\n\n<li><strong>\u591a\u5668\u5b98\u534f\u540c\u6a21\u62df<\/strong>\uff1aHNC \u8f6c\u79fb\u6d89\u53ca\u80ba\u3001\u9aa8\u7b49\u591a\u5668\u5b98\uff0c\u73b0\u6709<strong>\u591a\u5668\u5b98\u82af\u7247<\/strong>\u7684\u8840\u7ba1\u8fde\u63a5\u6280\u672f\u5c1a\u4e0d\u6210\u719f\uff0c\u9700\u8fdb\u4e00\u6b65\u6574\u5408<strong>\u5fae\u6d41\u63a7\u7cfb\u7edf<\/strong>\u4e0e\u5668\u5b98\u95f4\u7269\u8d28\u4ea4\u6362\u673a\u5236\u3002<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">\u672a\u6765\u65b9\u5411\u4e0a\uff0cHPV \u7279\u5f02\u6027\u82af\u7247\u5c06\u6210\u4e3a\u91cd\u70b9 \u2014\u2014 \u901a\u8fc7\u6784\u5efa HPV \u9633\u6027 \/ \u9634\u6027 HNC \u7684\u4e13\u5c5e TME \u6a21\u578b\uff08\u5982\u6574\u5408 HPV-16 E6\/E7 \u57fa\u56e0\u7684\u7c7b\u5668\u5b98\uff09\uff0c\u63ed\u793a\u75c5\u6bd2\u9a71\u52a8\u7684\u514d\u75ab\u9003\u9038\u673a\u5236\uff1b\u540c\u65f6\uff0c<strong>\u7c7b\u5668\u5b98\u82af\u7247<\/strong>\u4e0e AI \u7684\u7ed3\u5408\uff0c\u53ef\u5efa\u7acb\u836f\u7269\u54cd\u5e94\u9884\u6d4b\u6a21\u578b\uff0c\u63a8\u52a8\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6848\u7684\u81ea\u52a8\u5316\u751f\u6210\u3002\u6b64\u5916\uff0c<strong>\u5fae\u6d41\u63a7\u82af\u7247<\/strong>\u4e0e\u5f71\u50cf\u6280\u672f\uff08\u5982\u5171\u805a\u7126\u663e\u5fae\u955c\uff09\u7684\u8054\u7528\uff0c\u5c06\u5b9e\u73b0 TME \u4e2d\u7ec6\u80de\u4e92\u4f5c\u7684\u5b9e\u65f6\u53ef\u89c6\u5316\uff0c\u4e3a HNC \u53d1\u75c5\u673a\u5236\u7814\u7a76\u63d0\u4f9b\u65b0\u89c6\u89d2\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5668\u5b98\u82af\u7247\u6280\u672f\u4e0e 3D \u6a21\u578b\u7684\u53d1\u5c55\uff0c\u4e3a\u5934\u9888\u90e8\u764c\u7814\u7a76\u63d0\u4f9b\u4e86 \u201c\u4ece\u5b9e\u9a8c\u5ba4\u5230\u4e34\u5e8a\u201d \u7684\u7cbe\u51c6\u5de5\u5177\u3002\u901a\u8fc7<strong>PDMS <\/strong><strong>\u82af\u7247<\/strong>\u3001<strong>\u5fae\u6d41\u63a7\u52a0\u5de5<\/strong>\u3001<strong>\u7c7b\u5668\u5b98\u82af\u7247<\/strong>\u7b49\u6280\u672f\u7684\u6574\u5408\uff0c\u4e0d\u4ec5\u89e3\u51b3\u4e86\u4f20\u7edf\u6a21\u578b\u7684\u5c40\u9650\uff0c\u66f4\u5b9e\u73b0\u4e86\u5bf9 HNC \u5f02\u8d28\u6027\u3001TME \u590d\u6742\u6027\u7684\u6df1\u5ea6\u6a21\u62df\u3002\u672a\u6765\uff0c\u968f\u7740\u6807\u51c6\u5316\u8fdb\u7a0b\u7684\u63a8\u8fdb\u4e0e\u4ea7\u4e1a\u534f\u540c\u7684\u52a0\u5f3a\uff0c\u5668\u5b98\u82af\u7247\u5c06\u6210\u4e3a HNC \u836f\u7269\u7814\u53d1\u3001\u4e2a\u6027\u5316\u6cbb\u7597\u8bc4\u4f30\u7684\u6838\u5fc3\u5e73\u53f0\uff0c\u4e3a\u63d0\u5347\u60a3\u8005\u751f\u5b58\u7387\u4e0e\u6cbb\u7597\u8d28\u91cf\u63d0\u4f9b\u5173\u952e\u652f\u6491\uff0c\u63a8\u52a8\u5934\u9888\u90e8\u764c\u7814\u7a76\u8fdb\u5165 \u201c\u7cbe\u51c6\u5fae\u751f\u7406\u201d \u65f6\u4ee3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53c2\u8003\u6587\u732e\uff1ahttps:\/\/doi.org\/10.1186\/s12967-025-06824-5<\/p>\n\n\n\n<h3 class=\"wp-block-heading has-pale-cyan-blue-background-color has-background has-medium-font-size\">\u9876\u65ed\u5fae\u63a7\u4ea7\u54c1<\/h3>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"815\" height=\"623\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/image-11.png\" alt=\"\" class=\"wp-image-1637\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/image-11.png 815w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/image-11-600x459.png 600w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/image-11-768x587.png 768w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/image-11-16x12.png 16w\" sizes=\"auto, (max-width: 815px) 100vw, 815px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table has-small-font-size\"><table><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\" rowspan=\"2\"><strong>\u4ea7\u54c1\u7f16\u53f7<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\" rowspan=\"2\"><strong>\u5916\u5f62<\/strong><br><strong>\uff08mm\uff09<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\" colspan=\"3\"><strong>\u6d41\u9053<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\" colspan=\"2\"><strong>\u5fae\u5b54\u819c<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\" rowspan=\"2\"><strong>\u6750\u6599<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\" rowspan=\"2\"><strong>\u4ef7\u683c<\/strong><br><strong>\uff08CNY\uff09<\/strong><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u9ad8<\/strong><br><strong>\uff08mm\uff09<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u5bbd\u5ea6<\/strong><br><strong>\uff08mm\uff09<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u95f4\u8ddd<\/strong><br><strong>\uff08mm\uff09<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u539a\u5ea6<\/strong> <br><strong>\uff08um\uff09<\/strong><\/td><td class=\"has-text-align-center\" data-align=\"center\"><strong>\u5b54\u5f84<\/strong><br> <strong>\uff08um\uff09<\/strong><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">600001<\/td><td class=\"has-text-align-center\" data-align=\"center\">30*15<\/td><td class=\"has-text-align-center\" data-align=\"center\">0.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">1<\/td><td class=\"has-text-align-center\" data-align=\"center\">0.2<\/td><td class=\"has-text-align-center\" data-align=\"center\">25<\/td><td class=\"has-text-align-center\" data-align=\"center\">8<\/td><td class=\"has-text-align-center\" data-align=\"center\">PDMS<\/td><td class=\"has-text-align-center\" data-align=\"center\">800<\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">600002<\/td><td class=\"has-text-align-center\" data-align=\"center\">30*15<\/td><td class=\"has-text-align-center\" data-align=\"center\">0.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">1<\/td><td class=\"has-text-align-center\" data-align=\"center\">0.5<\/td><td class=\"has-text-align-center\" data-align=\"center\">25<\/td><td class=\"has-text-align-center\" data-align=\"center\">8<\/td><td class=\"has-text-align-center\" data-align=\"center\">PDMS<\/td><td class=\"has-text-align-center\" data-align=\"center\">800<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">\u672c\u4ef7\u683c\u4e3a\u4e2d\u56fd\u5927\u9646\u5730\u533a\u552e\u4ef7\uff0c\u4e3a\u4eba\u6c11\u5e01\u4ef7\u683c\uff0c\u4e2d\u56fd\u5927\u9646\u4ee5\u5916\u533a\u57df\u8bf7\u8054\u7cfb\u5ba2\u670d\u62a5\u4ef7\u3002(sale@dxfluidics.com)<\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading has-pale-cyan-blue-background-color has-background\">\u8ba2\u8d2d\u65b9\u5f0f<\/h3>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"140\" height=\"140\" data-id=\"1378\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/10\/image-26.png\" alt=\"\" class=\"wp-image-1378\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/10\/image-26.png 140w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/10\/image-26-100x100.png 100w\" sizes=\"auto, (max-width: 140px) 100vw, 140px\" \/><figcaption class=\"wp-element-caption\">           \u6dd8\u5b9d\u5e97\u94fa<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"396\" height=\"396\" data-id=\"823\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/02\/\u5434\u7115.png\" alt=\"\" class=\"wp-image-823\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/02\/\u5434\u7115.png 396w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/02\/\u5434\u7115-300x300.png 300w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2023\/02\/\u5434\u7115-100x100.png 100w\" sizes=\"auto, (max-width: 396px) 100vw, 396px\" \/><figcaption class=\"wp-element-caption\">           \u4f01\u4e1a\u5fae\u4fe1\uff08Tel:18112558497)<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"720\" data-id=\"1599\" src=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/R.jpg\" alt=\"\" class=\"wp-image-1599\" srcset=\"https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/R.jpg 900w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/R-600x480.jpg 600w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/R-768x614.jpg 768w, https:\/\/www.dxfluidics.com\/wp-content\/uploads\/2024\/01\/R-15x12.jpg 15w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><figcaption class=\"wp-element-caption\">   \u90ae\u7bb1\uff1asale@dxfluidics.com<\/figcaption><\/figure>\n<\/figure>\n","protected":false},"excerpt":{"rendered":"<p>1.&nbsp;&nbsp;&nbsp; \u5f15\u8a00\uff1a\u5934\u9888\u90e8\u764c\u7684\u4e34\u5e8a\u6311\u6218\u4e0e\u4f20\u7edf\u6a21\u578b\u5c40\u9650 \u5934\u9888\u90e8\u764c\uff08HNC\uff09\u4f5c\u4e3a\u5168\u7403\u7b2c [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_crdt_document":"","footnotes":""},"categories":[5],"tags":[],"class_list":["post-5224","post","type-post","status-publish","format-standard","hentry","category-information"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u5934\u9888\u90e8\u764c\u7814\u7a76\u4e2d\u5668\u5b98\u82af\u7247\u6280\u672f\u7684\u521b\u65b0\u5e94\u7528\u4e0e\u00a03D\u00a0\u6a21\u578b\u7a81\u7834 - \u9876\u65ed\u5fae\u63a7<\/title>\n<meta name=\"description\" content=\"\u5934\u9888\u90e8\u764c\uff08HNC\uff09\u7814\u7a76\u4e2d\uff0c\u5668\u5b98\u82af\u7247\u6280\u672f\uff08PDMS \u82af\u7247\u3001\u5fae\u6d41\u63a7\u82af\u7247\u7b49\uff09\u7a81\u7834\u4f20\u7edf\u6a21\u578b\u5c40\u9650\uff0c\u7ed3\u5408 3D 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